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Synthesis of chitosan/hydroxyapatite nanocomposite scaffolds for tissue engineering applications

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dc.contributor.advisor Adikary SU
dc.contributor.author Rajapakse HD
dc.date.accessioned 2024-08-05T05:30:19Z
dc.date.available 2024-08-05T05:30:19Z
dc.date.issued 2023
dc.identifier.citation Rajapakse, H.D. (2023). Synthesis of chitosan/hydroxyapatite nanocomposite scaffolds for tissue engineering applications [Master's theses, University of Moratuwa]. Institutional Repository University of Moratuwa. http://dl.lib.uom.lk/handle/123/22621
dc.identifier.uri http://dl.lib.uom.lk/handle/123/22621
dc.description.abstract The objective of this research was to extract chitosan from waste Crustacean shrimp shells of the species Penaeus Monodon, which is a by-product of the shrimp export industry. Then the extracted chitosan was used to synthesize chitosan/nanohydroxyapatite composite by co-precipitation of nanohydroxyapatite onto a chitosan scaffold. A number of characterization techniques were used to analyze the structure and composition of the extracted chitosan and the synthesized composite. The porous structure of chitosan and the Hydroxyapatite nanoparticles embedded in the chitosan matrix could be observed through scanning electron microscopy. Both scanning electron microscopic images and X-ray diffractograms confirmed the size of the nanohydroxyapatite to be in the range of 2-14 nanometers. From the energy dispersive X-ray analysis, a ratio by weight of 2:1 for Ca:P was obtained confirming the presence of hydroxyapatite in the composite. The thermograms obtained from the thermogravimetric analysis revealed that the decomposition temperature drops with increasing hydroxyapatite loading in the composite which can be attributed to the higher crystallinity and better heat transfer in the composite. The degradation studies revealed that the percent degradation increases with time as well as the HAp loading. The biomineralization study done with simulated body fluid depicts that the Ca concentration of the SBF solution decreases over time, this is due to the uptake of Ca2+ ions from the SBF solution to form the apatite layer on the scaffold. en_US
dc.language.iso en en_US
dc.subject CHITOSAN
dc.subject NANOHYDROXYAPATITE
dc.subject NANOCOMPOSITES
dc.subject BONE TISSUE ENGINEERING
dc.subject BIOACTIVITY
dc.subject MATERIALS SCIENCE - Dissertation
dc.subject MSc (Major Component Research)
dc.title Synthesis of chitosan/hydroxyapatite nanocomposite scaffolds for tissue engineering applications en_US
dc.type Thesis-Abstract en_US
dc.identifier.faculty Engineering en_US
dc.identifier.degree Master of Science (Major Component of Research) en_US
dc.identifier.department Department of Materials Science and Engineering en_US
dc.date.accept 2023
dc.identifier.accno TH5340 en_US


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