Design and development of an inhalation assist dpi to improve lung deposition

Abstract

A dry powder inhaler (DPI) is a small, handheld device that allows breathing in medicine through the mouth directly to the lungs to treat a wide variety of respiratory disorders. These disorders are not well controlled due to inefficient medicine delivery systems, poor treatment compliance, and inaccurate inhaler techniques. In dry powder inhalers, energy is needed for the deagglomeration of the drug and transport it into the lungs. Currently, available DPIs have a low lung drug deposition because deposition depends entirely on the patient’s inspiratory effort. Improvements are being made to introduce an internal energy to improve lung deposition